舒乐冲剂治疗脑卒中后抑郁的随机对照研究

目的观察舒乐冲剂治疗脑卒中后抑郁（PSD）的疗效及其对神经功能康复的影响。方法将41例PSD患者随机分为治疗组和对照组。治疗组口服舒乐冲剂，对照组服用盐酸氟西汀，两组患者在治疗前及治疗后6周进行汉密尔顿抑郁量表（HAMD）及神经功能缺损评分，并观察不良反应。结果在HAMD抑郁评分、神经功能缺损评分方面，两组治疗后与治疗前比较，均有统计学意义（P〈0．05）。治疗组治疗后量袁评分与盐酸氟西汀治疗疗效果相当，无统计学意义（P〉0．05）。两组临床疗效无统计学意义。结论舒乐冲剂能明显改善PSD患者的抑郁症状，有利于神经功能的恢复且无明显不良反应，安全性高。

A Randomized Controlled Clinical Study of Shule Granules in Treatment of Poststroke Depression

Objective To investigate the effect of Shule granule on the depressive behavior and nerve function rehabilitation in patients with poststroke depression（PSD）. Methods Forty - one patients with PSD were randomly divided into two groups：Treatment group treated with Shule granule and control group treated with fluoxetine. During six weeks of basic therapy,all patients were evaluated by the Hamiltion rating scale for depression（HAMD） and neurological function defect scores（NFDS）. Results There were significantly different in the total scores of HAMD and NFDS before and after treatment in two groups（P〈0.05）. The general effective- ness on the two groups was similar（P〉0.05）. The total scores of HAMD and NFDS were not obviously different between two groups before and after treatment（P〉0.05）. Conclusion Shule granule could improve poststroke depression remarkably and might be helpful for the neurological function recovery without adverse effects.