| 三种食管鳞癌细胞系的染色体异常研究 |
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| 引用本文： | 李晓昀 苏敏 ChinSF FitzgeraldRC CaldasC.三种食管鳞癌细胞系的染色体异常研究[J].中国癌症杂志,2005,15(5):446-449. |
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| 作者姓名： | 李晓昀 苏敏 ChinSF FitzgeraldRC CaldasC |
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| 作者单位： | 汕头大学医学院病理教研室，汕头大学医学院病理教研室，Hutchison/MRC Research Centre，University of Cambridge，Hills Road，Cambridge CB2 2XZ，UK，Hutchison/MRC Research Centre，University of Cambridge，Hills Road，Cambridge CB2 2XZ，UK，Hutchison/MRC Research Centre，University of Cambridge，Hills Road，Cambridge CB2 2XZ，UK 广东汕头515041，广东汕头515041 |
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| 基金项目： | 国家自然科学基金国际合作重点项目(30210103904)，广东省十五攻关项目(A1080203) |
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| 摘 要： | 目的:分析食管鳞癌(ESCC)细胞系的染色体异常,为将来寻找食管癌相关基因提供线索。方法:采用比较基因组杂交法(CGH)分析3种ESCC细胞系的染色体DNA拷贝数改变情况。结果:9q(3/3)、3q(2/3)、5q(2/3)、5p(2/3)、8q(2/3)、12p(2/3)和20q(2/3)为常见的染色体增加区。4q(2/3)和6q(2/3)是常见的染色体丢失区。结论:这些常见的染色体异常有助于寻找和定位食管癌相关基因。
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| 关 键 词： | 食管癌 染色体 培养的肿瘤细胞 比较基因组杂交 |
| 文章编号： | 1007-3639(2005)05-0446-04 |
| 收稿时间： | 2005-01-12 |
| 修稿时间： | 2005-03-21 |
Chromosomal aberrations in 3 esophageal squamous cell carcinoma cell lines |
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| LI Xiao-yun,SU Mi,Chin SF,et al.Chromosomal aberrations in 3 esophageal squamous cell carcinoma cell lines[J].China Oncology,2005,15(5):446-449. |
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| Authors: | LI Xiao-yun SU Mi Chin SF |
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| Institution: | 1.Department of pathology,Shantou University Medical College,Shantou Guangdong,515031,China; 2.Hutchison/MRC Research Centre,University of Cambridge,Hills Road,Cambridge CB2 2XZ,UK. |
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| Abstract: | Purpose:To analyze genetic aberrations of cell lines of esophageal squamous cell carcinoma(ESCC),providing the clues for identifying the location of esophageal cancer(EC)-related genes.Methods:We investigated chromosomal DNA copy number changes in 3 ESCC cell lines by comparative genomic hybridization(CGH).Results:9q(3/3),3q(2/3),5q(2/3),5p(2/3),8q(2/3),12p(2/3)and 20q(2/3)were frequent chromosome gain regions,and 4q(2/3)and 6q(2/3)were frequent chromosome loss regions.Conclusions:These common chromosomal abnormalities may help to identify candidate genes related to esophageal cancer |
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| Keywords: | Esophageal cancer chromosome caltured tumor cells comparative genomic hybridiyation |
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