有氧运动对冠心病患者C-反应蛋白及肿瘤坏死因子-α的影响

目的：探讨有氧运动对冠心病患者C-反应蛋白（CRP）及肿瘤坏死因子-α（TNF-α）的影响。方法：60例平时不运动的冠心病稳定型心绞痛患者被随机分为运动组（有氧运动＋药物治疗）、药物治疗组（单纯药物治疗），另选30例正常人作为正常对照组。所有人在治疗前与治疗24周结束后，以酶联免疫吸附试验测定血清中CRP，以放射免疫法测定血清中TNF-α水平；并测定实验前后的体重。结果：治疗前药物对照组及运动组血清CRP、TNF—α水平明显高于正常对照组（P〈0．05～〈0．01）。治疗24周后运动组血清中CRP、TNF—α水平明显下降，且低于药物治疗组（P〈0．05），但仍明显高于正常对照组（P〈0．05）；运动组病人体重明显低于药物治疗组（P〈0．05）。结论：有氧运动可以减轻冠心病患者的炎症反应，且伴有体重的减轻。

Effects of aerobic exercise on C-reactive protein and tumor necrosis factor α in coronary heart disease patients

To explore the effects of aerobic exercise on C--reactive protein （CRP） and Tumor necrosis factor （TNF）--α in coronary heart disease patients （CHD）. Methods： Sixty stable CHD patients were randomly divided into two groups： aerobic exercise group （exercise group, participated in a 12--week aerobic exercise training and with drug treatment） ; drug treatment group （drug control group, only treated with drag）. Another thirty health adults composed normal control group. Fasting blood samples were collected before treated and on 6 months after treated. CRP levels were measured by enzyme linked immunosorbent assay; TNF-α levels were measured by radio-immunity. Results.. Before treatment, the CRP and TNF--α level were more than those of normal control group （P〈0. 05 -0.01） ; After 24 weeks treatment, the body weight, CRP and TNF--α levels in exercise group considerably reduced and less than those of drag control group （P〈0.05 all）. Conclusion： Aerobic exercise training significantly decrease weight and exerts anti-inflammatory effects in patients with coronary heart disease.