老年2型糖尿病患者颈动脉病变与血清铜锌的关系

目的 探讨老年2型糖尿病患者大血管病变与血清微量元素的关系.方法 随机选择非老年2型糖尿病患者和老年2型糖尿病患者各90例,以90例健康体检者作为对照组.采用原子吸收光谱法测定血铜和血锌水平,超声检测颈动脉内膜中层厚度(IMT),同时检测患者血压、体重指数、血糖、血脂.将血铜和血锌水平与血压、体重指数、血糖、血脂和IMT值等进行Pearson相关性检验.结果 非老年组与老年组腰臀比和体重指数比较差异无统计学意义(P＞0.05).与非老年组比较,老年组的血压、血清FPG、HbA1c、HOMA-IR、TC、TG和LDL-C水平更高,而血清HDL-C水平则更低,差异有统计学意义(P＜0.05).与对照组比较,非老年组和老年组的血铜水平、铜/锌比值和IMT值显著升高,而血锌水平显著降低,差异有统计学意义(P＜0.05).与非老年组比较,老年组上述指标变化更明显(P＜0.05).直线相关分析显示:非老年组和老年组的血铜水平与IMT、FPG和HbA1c呈正相关;而血锌水平与IMT、FPG和HbA1c呈负相关.结论 老年糖尿病患者的血铜水平升高以及血锌水平降低可能是IMT增厚的一个因素.

Relationship of Serum Copper and Zinc Levels to Carotid Intima-media Thickness of Elderly Patients with Type 2 Diabetes Mellitus

Objective To investigate the relationship between carotid intima-media thickness(IMT)and serum microelements of elderly patients with type 2 diabetes.Methods 180 patients with type 2 diabetes were divided into non-elderly group and elderly group,and 90 healthy people were chosen as control group.Serum levels of copper and zinc were detected by atomic absorption spectroscopy.Blood pressure,body mass index,blood sugar,blood fat and IMT were also detected and compared among different groups.Pearson correlation test was applied in the study.Results Blood pressure in elderly group was significantly higher than non-elderly group and control group(P<0.05).There was no statistical difference in waist-to-hip ratio and body mass index between non-elderly group and elderly group(P>0.05).Compared to non-elderly group,the serum levels of FPG,HbA1c,HOMA-IR,TC,TG and LDL-C were statistically higher,and the serum levels of HDL-C was statistically lower in elderly group(P<0.05).Compared to control group,serum levels of copper in non-elderly group and elderly group were statistically higher,but serum levels of zinc were statistically lower(P<0.05).Compared to non-elderly group,serum level of copper in elderly group was statistically higher,but serum level of zinc was statistically lower(P<0.05).Pearson correlation tests showed that serum level of copper was positively correlated with IMT and blood sugar,and serum level of zinc was negatively correlated with IMT and blood sugar both in on-elderly group and elderly group.Conclusion High level of serum copper and low level of serum zinc may play an important role on IMT in elderly patients with diabetes.