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尾型同源转录因子-2和糖链抗原242蛋白在老年结直肠癌中的表达及其与临床病理特征的关系
引用本文:谷化平,尚培中.尾型同源转录因子-2和糖链抗原242蛋白在老年结直肠癌中的表达及其与临床病理特征的关系[J].华北国防医药,2012,24(1):8-10.
作者姓名:谷化平  尚培中
作者单位:1. 张家口,解放军251医院病理科,河北,075000
2. 张家口,解放军251医院普通外科,河北,075000
摘    要:目的 探讨尾型同源转录因子-2(CDX2)和糖链抗原242(CA242)蛋白表达与老年结直肠癌临床病理特征的关系.方法 应用免疫组化技术检测90例老年结直肠癌组织和30例正常结直肠黏膜组织中CDX2和CA242蛋白的表达情况.结果 老年结直肠癌组织中CDX2阳性表达率(65.6%)显著低于正常结直肠黏膜组织(93.3%,P<0.05),而CA242蛋白阳性表达率(75.6%)显著高于正常结直肠黏膜组织(10.0%,P<0.05).CDX2和CA242蛋白的表达与老年结直肠癌的分化程度、Duke's分期、浆膜浸润和淋巴结转移相关(P<0.05).CDX2与CA242蛋白的表达呈显著负相关(r=-0.30,P<0.05).结论 CDX2和CA242蛋白表达与老年结直肠癌浸润转移密切相关,联合检测其蛋白表达可作为判断老年结直肠癌预后的客观参考指标.

关 键 词:结直肠肿瘤  老年人  基因表达调控  肿瘤  尾型同源转录因子-2  糖链抗原242  免疫组织化学

Relationship between Expressions of CDX2 and CA242 Protein in Colorectal Cancer and its Clinicopathological Features in Elderly Patients
GU Hua-ping,SHANG Pei-zhong.Relationship between Expressions of CDX2 and CA242 Protein in Colorectal Cancer and its Clinicopathological Features in Elderly Patients[J].Medical Journal of Beijing Military Region,2012,24(1):8-10.
Authors:GU Hua-ping  SHANG Pei-zhong
Institution:(The 251^st Hospital of PLA a. Department of Pathology; b. Department of General Surgery, the 251^st Hospital of PLA, Zhangjiakou, Hebei 075000, China)
Abstract:Objective To investigate the relataionship between the expressions of CDX2 and CA242 protein and their clinicopatholoic in colorectal cancer in elderly patients. Methods Immunohistochemical staining was used to detect the expressions of CDX2 and CA242 protein in 90 cases of colorectal carcinoma and 30 cases of normal colorectal mueosa. Results The expressions of CDX2 and CA242 of the carcinoma were 65.6% (59/90) and 75.6% (68/90) , respectively. CDX2 protein was lower than that in normal colorectal mucosa (93.3% , P 〈0.05) , but the CA242 protein in carcinoma was higher than that in mormal coloreetal mucosa ( 10.0% , P 〈 0.05 ). The expressions of CDX2 protein and CA242 protein were positively correlated with tumor grading, Duke's staging, serosa infiltration and lymph node metastasis of eolorectal cancer ( r = - 0.30, P 〈 0.05 ). Negative correlation was found between CDX2 and CA242 protein ( P 〈 0.05 ). Conclusion The study shows that a correlation exists between the CDX2 protein and CA242 protein expressions and the potential of invasion and metastasis in colorectal cancer. CDX2 and CA242 protein may be prognostic indicators in colorectal cancer in elderly patients.
Keywords:Colorectal carcinoma  Aged  Gene expression regulation  neoplastic  CDX2  CA242  Immunohistoehemistry
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