肺癌患者手术前后血清NSE、CYFRA21-1、CEA的变化及临床意义

目的 探讨血清神经元烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及癌胚抗原(CEA)在肺癌患者手术前后的水平变化及临床意义.方法 选择肺癌患者105例,肺良性病变患者54例.采用电化学发光法检测了手术前后血清NSE、CYFRA21-1、CEA水平.结果 肺癌组血清NSE和CYFRA21-1、CEA水平高于胃良性疾病组,差异有统计学意义(P<0.01).肺癌患者行根治性手术组术后血清NSE、CYFRA21-1、CEA水平明显低于手术前,差异有统计学意义(P<0.01).结论 手术切除肿瘤特别是行根治性切除术后,血清NSE、CYFRA21-1、CEA水平显著降低,动态观察NSE、CYFRA21-1、CEA水平及其变化,对肺癌的辅助诊断、预后判断有重要的价值.

Changes of serum NSE,CYFRA21-1 and CEA in patients with lung cancer before after operation and related clinical significance analysis

Objective To explore the changes of serum neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1) and carcinoembryonic antigen(CEA) in patients with lung cancer before and after operation and related clinical significance.Methods Electrochemiluminescene analyzer was used to detect the content of serum NSE,CYFRA21-1 and CEA in 105 patients with lung cancer(cancer group) and 47 control patients with benign lung diseases(benign diseases group).Results The contents of NSE,CYFRA21-1 and CEA in cancer group were higher than those in benign diseases group(P<0.01),and in cancer group,detected results of the three indexes were significantly decreased after radical surgery(P<0.01).Conclusion Radical resection could reduce the content of NSE,CYFRA21-1 and CEA in patients with lung cancer.To dynamically determine serum level of NSE,CYFRA21-1 and CEA might be very useful for the auxiliary diagnosis and prognosis of lung cancer.