| 调节性T细胞相关负性分子与感染免疫 |
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| 引用本文： | 赵慧,王晶,魏晓丽,丁剑冰. 调节性T细胞相关负性分子与感染免疫[J]. 免疫学杂志, 2012, 0(2): 169-173 |
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| 作者姓名： | 赵慧 王晶 魏晓丽 丁剑冰 |
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| 作者单位： | 新疆医科大学第一附属医院包虫病重点实验室;新疆医科大学附属中医院;新疆医科大学免疫学教研室 |
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| 基金项目： | 国家自然科学基金项目(30860263,30901374,81060135,30560146) |
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| 摘 要： | 调节性T细胞通过免疫抑制与免疫耐受机制影响疾病的发展。与调节性T细胞相关的CTLA-4、PD-1等负性分子在调节性T细胞的调节功能中起重要作用。本文拟对CTLA-4、PD-1和调节性T细胞的关系以及在病毒感染、细菌感染、寄生虫感染等免疫病中的调节机制作一综述。
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| 关 键 词： | CTLA-4 PD-1 调节性T细胞 感染免疫 |
The relationship between the negative immune molecules of regulatory T cells and infection immunity |
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| ZHAO Hui,WANG Jin,WEI Xiaoli,DING Jianbing. The relationship between the negative immune molecules of regulatory T cells and infection immunity[J]. Immunological Journal, 2012, 0(2): 169-173 |
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| Authors: | ZHAO Hui WANG Jin WEI Xiaoli DING Jianbing |
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| Affiliation: | Xinjiang Key Lab of Echinococcosis,the First Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China |
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| Abstract: | Regulatory T cells affect the development of diseases by immune suppression and immune tolerance.CTLA-4,PD-1 and other negative regulatory molecules associated with regulatory T cells play the important roles in regulating function.This review is focused on the relationship between CTLA-4,PD-1 and regulatory T cells,and on the regulating role in viral infections,bacterial infections,parasitic infections and other immune diseases. |
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| Keywords: | CTLA-4 PD-1 Regulatory T cells Infection immunity |
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