STAT3及SOCS3在鼻息肉患者中对Th17分化的作用观察

The role of STAT3 and SOCS3 in Th17 polarization in nasal polyposis

Nasal polyposis(NP) is a chronic inflammatory disease of the paranasal sinuses characterized by a prominent Th17 response.STAT3 plays a key role in regulating Th17 cells polarization.The aim of the present study is to explore the roles of STAT3 and its related signal molecules in patients with NP.We analyzed the expression of p-STAT3,SOCS3,IL-6,IL-17A and RORγt in the sinus tissue of 40 NP patients and 15 controls using mRNA and protein detection methods.Expression of p-STAT3,IL-6,IL-17A and RORγt in NP group was significantly higher than those in control group(P<0.01).Whereas,the SOCS3 was lower in NP group compared with the control group(P<0.01).Furthermore,the significantly negative correlation between p-STAT3 and SOCS3 was found(r=-0.545,P<0.01),and SOCS3 was also negative associated with RORγt and IL-17A(RORγt/SOCS3:r=-0.627,P<0.05;IL-17A/SOCS3:r=-0.631,P<0.01);while p-STAT3 was positive correlated with RORγt,IL-6 and IL-17A(p-STAT3/RORγt:r=0.594,P<0.001;p-STAT3/IL-6:r=0.632,P<0.001;p-STAT3/IL-17A:r=0.647,P<0.01).Our data suggest that aberrant activation of STAT3 and the deficiency of inhibition effect of SOCS3 might be one of factors to contribute to Th17 polarization in nasal polyposis.