| 肾细胞癌中CD24蛋白的表达及其临床意义 |
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| 引用本文： | 张永红,曾甫清.肾细胞癌中CD24蛋白的表达及其临床意义[J].临床泌尿外科杂志,2007,22(3):219-220. |
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| 作者姓名： | 张永红 曾甫清 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院泌尿外科,武汉,430022 |
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| 摘 要： | 目的：探讨CD24蛋白在肾细胞癌中的表达及与肾细胞癌临床特征的关系。方法：采用免疫组织化学SP法检测了60例肾细胞癌组织中CD24蛋白的表达。结果：在60例肾细胞癌组织中，41例（68．33％）CD24蛋白表达阳性。随着肿瘤细胞病理分级、临床分期的升高，CD24蛋白表达阳性率随之增高，且各组间比较差异有统计学意义（P〈0．05）。远隔肿瘤旁正常肾组织无CD24蛋白表达。结论：CD24蛋白表达与肾细胞癌临床分期、病理分级呈密切正相关（P〈0．05）。CD24蛋白在肿瘤的发生、发展中起重要作用，且可能成为判断肾细胞癌患者无病生存的预后指标。
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| 关 键 词： | 肾细胞癌 CD24蛋白 预后指标 |
| 文章编号： | 1001-1420（2007）03-0219-02 |
| 收稿时间： | 2007-01-15 |
| 修稿时间： | 01 15 2007 12:00AM |
Clinical significance of CD24 protein expression in human renal cell carcinoma |
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| ZHANG Yonghong,ZENG Fuqing.Clinical significance of CD24 protein expression in human renal cell carcinoma[J].Journal of Clinical Urology,2007,22(3):219-220. |
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| Authors: | ZHANG Yonghong ZENG Fuqing |
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| Institution: | 1 Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Sci- ence and Technology, Wuhan, 430022, China |
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| Abstract: | Objective:To investigate the clinical significance of CD24 protein expression in human renal cell carcinoma.Methods: CD24 protein expression of 60 renal cell carcinomas were analysed by SP immunohistochemistry.Results:All normal renal tissues had negtive expression of CD24 protein.The positive rate of CD24 protein expression in renal cellcarcinoma was 68.33%(41/60).The higher the grade and the clinical stage of tumor were, the lower the expression of CD24 protein,and the differences between groups are of statistical significance(P<0.05).Conclusions:The expression of CD24 protein has positive correlation with the grade and the clinical stage of tumor(P<0.05). The expression of CD24 protein may play a significant role in the development of the renal cell cancer and be a prognostic marker for disease-free survival in the renal cell cancer. |
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| Keywords: | Renal cell carcinoma CD24 protein Prognostic marker |
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