| 五龙克糖口服液对2型糖尿病大鼠胰岛β细胞的保护作用 |
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| 引用本文： | 胡衍园,文秀英,石珺,许明望. 五龙克糖口服液对2型糖尿病大鼠胰岛β细胞的保护作用[J]. 中国中西医结合杂志, 2003, 0(Z1) |
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| 作者姓名： | 胡衍园 文秀英 石珺 许明望 |
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| 作者单位： | [1]华中科技大学同济医学院附属梨园医院中西医结合科 [2]（武汉430077） |
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| 摘 要： | 目的:观察五龙克糖口服液对2型糖尿病大鼠胰岛分泌功能的影响。方法:采用链脲佐菌素和高热量饲养的方法模拟2型糖尿病大鼠模型,研究五龙克糖口服液对2型糖尿病大鼠 HOMA-β细胞分泌指数的影响,并用免疫组化法观察胰岛细胞中胰岛素的表达,同时作 HE 染色。结果:五龙克糖口服液可显著提高 HOMA-β细胞分泌指数(P<0.01),明显增强胰岛细胞中胰岛素表达(P<0.01),对胰岛内分泌细胞有一定修复功能。结论:五龙克糖口服液能促进被损伤的胰岛β细胞修复,从而改善胰岛β细胞功能。
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| 关 键 词： | 五龙克糖口服液 2型糖尿病 β细胞分泌指数 免疫组织化学 胰岛β细胞 |
Protection of Wulong Ketang Oral Liquid on Pancreatic Islet β Cells of Type Ⅱ Diabetes |
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| Affiliation: | HU Yan-yuan WEN Xiu-ying SHI Jun Department of Integrated Traditional and Western Medicine; Liyuan Hospital Affiliated to Tongji Medical College; Huazhong Scientific and Technological University; Wuhan(430077); |
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| Abstract: | Objective:To observe the effect of Wulong Ketang Oral Liquid (WLJT) on the secretion of pancreas islets of type Ⅱ diabetes. Methods:Model of type Ⅱ diabetes was simulated by the methods of injecting streptozotocin and feeding with high calorie diet to study the effect of WLJT to the secretion indices of HOMA-β cells.Immunohistochemical study was adopted to observe the expression of insulin in islet cells.In the meanwhile,HE staining was used to observe the morphology of islets.Results:WLJT could signifi- ca... |
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| Keywords: | Wulong Ketang Oral Liquid Type Ⅱ diabetes secretion index of β cells immunohistochemistry islet β cells |
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