| 去甲万古霉素对202株凝固酶阴性葡萄球菌的体外抗菌活性研究 |
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| 引用本文： | 李仲兴,杨永昌,赵建宏,杨敬芳,时东彦. 去甲万古霉素对202株凝固酶阴性葡萄球菌的体外抗菌活性研究[J]. 河北医科大学学报, 2007, 28(5): 337-340 |
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| 作者姓名： | 李仲兴 杨永昌 赵建宏 杨敬芳 时东彦 |
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| 作者单位： | 1. 河北医科大学第二医院检验科,河北,石家庄,050000
2. 北京军区总医院检验科,北京,100710 |
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| 摘 要： | 目的 观察国产去甲万古霉素对202株凝固酶阴性葡萄球菌(coagulase-negative staphylococci,CNS)的体外抗菌活性.方法 用二倍琼脂稀释法分别测定其最低抑菌浓度(minimal inhibitory concentration,MIC)并与进口万古霉素进行了抑菌效果对比.结果 国产去甲万古霉素对202株CNS的MIC50和MIC90分别为2 mg/L和4 mg/L.去甲万古霉素对124株表皮葡萄球菌、42株溶血葡萄球菌和14株里昂葡萄球菌的MIC90均为4 mg/L.结论 去甲万古霉素对CNS的抗菌效果很好,202株CNS对两种万古霉素的敏感率均为100%.
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| 关 键 词： | 去甲万古霉素 万古霉素 葡萄球菌科 微生物敏感性实验 |
| 文章编号： | 1007-3205（2007）05-0337-04 |
| 修稿时间： | 2007-01-152007-03-06 |
OBSERVATION OF ANTIBACTERIAL ACTIVITY OF DOMESTIC VANCOMYCIN AGAINST 202 STRAINS COAGULASE-NEGATIVE STAPHYLOCOCCUS ( S. EPIDERMIDIS, S. HEAMOLYTICUS ETC. ) IN VITRO |
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| LI Zhong-xing,YANG Yong-chang,ZHAO Jian-hong,YANG Jing-fang,SHI Dong-yan. OBSERVATION OF ANTIBACTERIAL ACTIVITY OF DOMESTIC VANCOMYCIN AGAINST 202 STRAINS COAGULASE-NEGATIVE STAPHYLOCOCCUS ( S. EPIDERMIDIS, S. HEAMOLYTICUS ETC. ) IN VITRO[J]. Journal of Hebei Medical University, 2007, 28(5): 337-340 |
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| Authors: | LI Zhong-xing YANG Yong-chang ZHAO Jian-hong YANG Jing-fang SHI Dong-yan |
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| Affiliation: | 1. Department of Laboratory, the Second Hospital of Hebei Medical University, Shijiazhuang O50000,China 2. Department of Laboratory, the General Hospital of Beijing Military Area, Beijing 100710, China |
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| Abstract: | Objective To evaluate the antibacterial activity of demethyl vancomycin against coagulase-negative staphylococci(CNS)(S.epidermidis,S.heamolyticus,etc) in vitro.Methods Deterimination of antibacterial activity of demethyl vancomycin against 202 of strains CNS(S.epidermidis,S.heamolyticus,etc) was performed using agar dilution method,and the antibacterial activity of demethyl vancomycin was compared with vancomycin(Lilly).Results The antibacterial efficiency of demethyl vancomycin against 202 strains CNS(S.epidermidis,S.heamolyticus,S lugdunensis,etc) was good,and the MIC50 and MIC90 of it against CNS(methicillin-resistant and methicillin-sensitive) were 2 and 4 mg/L respectively.Conclusion Demethyl vancomycin had strong antibacterial activity against 202 strains of coagulase-negative staphylococci,and the sensitive rates of demethyl vancomycin and vancomycin were all 100%. |
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| Keywords: | demethyl vancomycin vancomycin staphylococcaceae microbial sensitivitytests |
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