Influence of electrical stimulation of the posterior hypothalamus on musculocutaneous and renal circulation in anesthetized dogs |
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Authors: | Donald L F Wellens Adalbert H L van Bogaert Annie M J De Wilde Pierre Paul P M van Bogaert Jan L M Bleys |
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Institution: | (1) Cardiovascular Laboratories of the Born-Bunge Research Foundation, Berchem and of Janssen Pharmaceutica, Beerse, Belgium |
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Abstract: | Summary Hypertension and tachycardia were consistently induced by electrical stimulation of the median posterior hypothalamus in dogs under chloralose anesthesia, curarized and artificially ventilated. When renal and femoral vascular beds were perfused at a constant blood flow, the renal perfusion, pressure markedly increased, whereas only minor variations of the femoral perfusion pressure occurred. When the renal and femoral vessels were perfused by the heart at the prevailing blood pressure, peri-arterial electromagnetic flow measurements revealed that renal flow decreased and that femoral flow increased during hypothalamic hypertension, both before and after vagotomy. In the same animals, no significant changes of renal or femoral flow occurred during reflexogenic hypertension induced by carotid occlusion. These marked hemodynamic differences between the reflexogenic and the hypothalamic type of hypertension were consistently and repeatedly observed. The indications that baroreflex counter-regulation and ganglionic inhibition due to elevated catecholaminemia contribute to the relative lack of femoral vasoconstriction during hypothalamic hypertension, are discussed.Partly supported by grant nr. 2034 from I.W.O.N.L., Belgium |
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Keywords: | Hypothalamic stimulation Baroreflex Modulation Blood Pressure Renal Circulation Femoral Circulation |
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