Safety factor for neuromuscular transmission at type-identified diaphragm fibers |
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| Authors: | Ermilov Leonid G Mantilla Carlos B Rowley Katharine L Sieck Gary C |
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| Affiliation: | Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Joseph 4-184W, Rochester, Minnesota 55905, USA. |
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| Abstract: | The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity. |
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| Keywords: | motor unit phrenic motoneurons plasticity synaptic efficacy ventilation |
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