原发性女性生殖器恶性黑色素瘤16例分析

目的：探讨原发性女性生殖器恶性黑色素瘤的临床病理特点及合理的治疗方法。方法：对16例原发性女性生殖器恶性黑色素瘤的临床资料进行回顾性分析。结果：发生于外阴9例，阴道5例，子宫颈2例。全部病例均行手术加化疗综合治疗，行区域淋巴结清扫11例，4例有转移，转移率36.3％。存活＜2年8例，≥2年8例，其中≥5年仅2例。结论：原发性女性生殖器恶性黑色素瘤预后差，行根治手术辅化疗和免疫治疗，可望提高生存期。

Analysis of 16 female patients with primary malignant melanoma in the genital

Objective:To investigate the clinical pathological characterstics and the rational approaches to primary malignant melanoma in the genitalia.Methods:Clinical data of 16 female patients with primary malignant genital melanona were analysed retrospectively.Results:Nine tumors occurred in the vulva,5 in the vagina and 2 in uterine cervix.All patients were treated by surgery combined with chemotherapy.Eleven of them underwent lymphadenectomy and four had metastasis.The metastasis rate was 36.3%.The survival time was shorter than two years in eight patients.Eight patients were alive for more than or equal to two years and only two of them were alive for more than five years.Conclusions:The prognosis of primary malignant genital melanoma is poor.Radical surgery combined with chemotherapy and immunotherapy may prolong the survival time .