去炎松-A和5-氟脲嘧啶联合注射治疗增生性瘢痕及瘢痕疙瘩

目的:探索和评价去炎松-A和5-氟脲嘧啶联合注射治疗增生性瘢痕及瘢痕疙瘩的疗效。方法:58例病人随机分为治疗组和对照组。治疗组为应用去炎松-A和5-氟脲嘧啶增生性瘢痕及瘢痕疙瘩内注射,对照组单独用去炎松-A增生性瘢痕及瘢痕疙瘩内注射。比较两组痊愈率和有效率。结果:所有病例随访12～18个月。治疗组和对照组痊愈率分别为75.86%及48.28%,有效率分别为93.1%及72.41%;痊愈率和有效率差异显著。结论:去炎松-A和5-氟脲嘧啶联合注射治疗增生性瘢痕的疗效显著,安全可靠。

Observation of therapeutic effect on hypertrophic scars and keloid after treatment with intralesinal triamcinolone acetonide mixed with 5-fluorourcil

Objective To evaluate the effects of intralesinal triamcinolone acetonide mixed with 5-fluorourcil on hypertrophic scars. Methods 58 cases patients with hypertrophic scar and keloid were randomly divided into the treatment group and the control group.The hypertrophic scars and keloid were injected intralesionally with triamcinolone acetonide mixed with 5-fluorouracil(treatment group), triamcinolone acetonide(control group). The curative rate and effective rate of those two groups were compared. Results All cases were followed up from 12~18 months. The curative rate was 75.86 %(treatment group )and 48.28 %(control group ); the effective rate was 93.1 %(treatment group )and 72.41 %(control group ). The different of curative rate and effective rate between treatment group and control group is significant. Conclusion The therapeutic effect on hypertrophic scars and keloid after treatment with intralesinal triamcinolone acetonide mixed with 5-fluorourcil appears to be both effective and safe.