| 药物的油—水分配系数与鼻腔吸收研究 |
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| 引用本文： | 蒋新国,陆翔,崔景斌,邱亮,奚念朱.药物的油—水分配系数与鼻腔吸收研究[J].药学学报,1997,32(6):458-460. |
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| 作者姓名： | 蒋新国 陆翔 崔景斌 邱亮 奚念朱 |
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| 作者单位： | 上海医科大学生物药剂学研究室，上海医科大学 |
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| 摘 要： | 以油—水分配系数作为药物理化性质的一个指标,研究其与鼻腔吸收的关系。以脂溶性不同的盐酸地尔硫和对乙酰氨基酚为模型药物,用大鼠鼻腔在体重循环法研究了它们在不同pH条件下的鼻粘膜吸收速度常数,同时也测定了相应条件下的辛醇—水分配系数。结果表明,药物透鼻粘膜能力与其油—水分配系数有良好的相关性(γ=0.9761,n=9),提示鼻腔粘膜的性质与多数生物膜相似,脂溶性大的药物容易通过,而亲水性药物的通透性则较低。
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| 关 键 词： | 鼻腔吸收 油—水分配系数 大鼠鼻腔在体重循环试验 |
| 收稿时间： | 1995-11-07 |
STUDIES ON OCTANOL WATER PARTITION COEFFICIENT AND NASAL DRUG ABSORPTION |
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| XG Jiang,X Lu,JB Cui,L Qiu and NZ Xi.STUDIES ON OCTANOL WATER PARTITION COEFFICIENT AND NASAL DRUG ABSORPTION[J].Acta Pharmaceutica Sinica,1997,32(6):458-460. |
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| Authors: | XG Jiang X Lu JB Cui L Qiu and NZ Xi |
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| Institution: | Division of Biopharmaceutics, Shanghai Medical University, Shanghai 200032. |
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| Abstract: | In order to find out the quantitative relationship between physicochemical properties of drugs and their nasal absorption, diltiazem hydrochloride and paracetamol were selected as model drugs and their octanol water partition coefficient was determined. In situ nasal recirculation method at different pH values was used to estimate the rate constant of nasal drug absorption in rats. Results showed that quantitative relationship existed between partition coefficient and nasal absorption constant, with correlation coefficient being 0 9761( n =9). Besides methods of partition coefficient determination, the in situ nasal recirculation manipulation was also improved. |
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| Keywords: | Nasal absorption Oil water partition coefficient In situ rat nasal recirculation test |
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