1 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;2 The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;3 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland;4 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;8 Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland;5 Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts;6 Department of Internal Medicine, Medical University Hospital, Tuebingen, Germany;7 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland