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Design of a Semisolid Vaginal Microbicide Gel by Relating Composition to Properties and Performance

Authors:	Mahalingam Alamelu Smith Eric Fabian Judit Damian Festo R. Peters Jennifer J. Clark Meredith R. Friend David R. Katz David F. Kiser Patrick F.

Affiliation:	(1) Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112-5820, USA;(2) Department of Bioengineering, University of Utah, Salt Lake City, UT 84112-5820, USA;(3) Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA;(4) CONRAD, 1911 North Fort Myer Drive, Suite 900, Arlington, VA 22209, USA;(5) Department of Bioengineering, University of Utah, 20 S. 2030 E., Rm. 108, Salt Lake City, UT 84112-9458, USA;

Abstract:	Purpose Develop a preclinical in vitro algorithm enabling de novo design of semisolid vaginal drug delivery gels, by using biomechanical modeling of gel spreading in the vaginal canal and empirically relating gel composition to mechanical properties and predicted performance.

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