| 络石藤三萜总皂苷抗疲劳作用的实验研究 |
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| 引用本文： | 谭兴起,郭良君,孔飞飞,吕圭源,陈素红,张丽丹,周桂芬,张跃文,方慧.络石藤三萜总皂苷抗疲劳作用的实验研究[J].解放军药学学报,2011,27(2):128-131. |
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| 作者姓名： | 谭兴起 郭良君 孔飞飞 吕圭源 陈素红 张丽丹 周桂芬 张跃文 方慧 |
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| 作者单位： | 1. 解放军98医院, 浙江湖州,313000
2. 浙江中医药大学, 浙江杭州,310000 |
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| 摘 要： | 目的 探讨络石藤三萜总皂苷的抗疲劳作用.方法 ICR小鼠72只,随机分成6组.通过小鼠力竭游泳实验制备疲劳模型,络石藤三萜总皂苷以100,200,400 mg/kg的剂量灌胃给药,连续15d,观察小鼠的体质量变化、负重游泳时间、全血乳酸及血浆尿素氮、丙二醛含量.结果 络石藤三萜总皂苷能延长小鼠负重力竭游泳时间,降低定量...
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| 关 键 词： | 络石藤 三萜总皂昔 抗疲劳 LD BUN MDA |
Studies on the Anti-fatigue Effect of the Total Triterpenoid Saponins of Trachelospermi Coulis et Folium |
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| TAN Xing-qi,GUO Liang-jun,KONG Fei-fei,LV Gui-yuan,CHEN Su-hong,ZHANG Li-dan,ZHOU Gui-fen,ZHANG Yue-wen,FANG Hui.Studies on the Anti-fatigue Effect of the Total Triterpenoid Saponins of Trachelospermi Coulis et Folium[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(2):128-131. |
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| Authors: | TAN Xing-qi GUO Liang-jun KONG Fei-fei LV Gui-yuan CHEN Su-hong ZHANG Li-dan ZHOU Gui-fen ZHANG Yue-wen FANG Hui |
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| Institution: | 1.Hospital 98 of PLA, Huzhou 313000, China ; 2.Zhejiang Chinese Medical University, Hangzhou 310000, China) |
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| Abstract: | Objective To study the anti-fatigue effect of the total triterpenoid saponins of Trachelospermum Jasminoides（Lindl.） lem on ICR mice.Methods 72 selected male mice（using swimming ability as preliminary screening） were divided randomly into 6 groups.Through the exercise exhaustive mice model,the dosage of total triterpenoid saponins taken by the mice in the experimental groups were 100,200,400 mg/（kg·d）.After 15 days,the weight,time of loading swimming,blood lactic acid,blood urea nitrogen,malondialdehyd were determined respectively in mice.Results Total triterpenoid saponins lengthened the time of loading swimming,decreased obviously the contents of blood lactic acid（LD）,blood urea nitrogen（BUN）,and malondialdehyd（MDA）.Conclusion Total triterpenoid saponins has anti-fatigue effect. |
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| Keywords: | LD BUN MDA |
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