| 喷替酸锌钠对铅中毒小鼠的驱铅作用研究 |
| |
| 引用本文： | 杨树,陈立,尹艳艳,董俊兴.喷替酸锌钠对铅中毒小鼠的驱铅作用研究[J].解放军药学学报,2011,27(2):147-149. |
| |
| 作者姓名： | 杨树 陈立 尹艳艳 董俊兴 |
| |
| 作者单位： | 1. 安徽医科大学基础医学院药理学研究室, 安徽合肥,230032
2. 军事医学科学院放射与辐射医学研究所, 北京,100850 |
| |
| 摘 要： | 目的 研究喷替酸锌钠对慢性铅中毒小鼠体内铅的排泄效果,为临床用药提供实验依据.方法 小鼠随机分为6组,连续10d腹腔注射醋酸铅溶液,每日剂量为10 mg/kg,建立小鼠慢性铅中毒模型,末次染铅后24 h开始给药,连续7d肌肉注射喷替酸锌钠或Ca-DTPA,喷替酸锌钠每日剂量分别为50,150,450 mg/kg,Ca-...
|
| 关 键 词： | 喷替酸锌钠 铅中毒 排铅 |
Study of the Effect of Pentetate Zinc Trisodium on Excretion of Lead in Lead Poisoned Mice |
| |
| YANG Shu,CHEN Li,YIN Yan-yan,DONG Jun-xing.Study of the Effect of Pentetate Zinc Trisodium on Excretion of Lead in Lead Poisoned Mice[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(2):147-149. |
| |
| Authors: | YANG Shu CHEN Li YIN Yan-yan DONG Jun-xing |
| |
| Institution: | 1.Department of Pharmacology, College of Bacis .Medicine, Anhui Medical University, Hefei 230032, China ; 2.Institute of Radiation Medicine, Academy of Military Medical Sciences,Beijing !00850,China) |
| |
| Abstract: | Objective To provide experimental evidence for clinical use of the drug by studying the effect of pentetate zinc trisodium(Zn-DTPA) on excretion of lead in chronic lead poisoned mice.Methods Mice were randomly divided into six groups.The lead poisoned mice model was established by injecting lead acetate intraperitoneally once daily for ten consecutive days at a daily dose of 10 mg/kg.Then pentetate zinc trisodium or pentetate calcium trisodium was administered intramuscularly to mice once daily for seven co... |
| |
| Keywords: | pentetate zinc trisodium lead poisoning excretion of lead |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
