Mechanisms of chromium toxicity in mammalian cell cultures |
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| Authors: | Vera Bianchi Roberto Dal Toso Patrizia Debetto Angelo Gino Levis Sisto Luciani Franca Majone Gianni Tamino |
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| Affiliation: | 1. Institute of Animal Biology, Via Loredan 10, University of Padua, 35100 Padova, Italy;2. Institute of Pharmacology, Largo E. Meneghetti 2, University of Padua, 35100 Padova Italy |
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| Abstract: | Our observations about the cytotoxic and cytogenetic effects of hexavalent and trivalent chromium compounds in mammalian cells cultured in vitro are reviewed. Additional data concerning the induction of chromosomal aberrations and sister chromatid exchanges, the inhibition of nucleic acid and protein synthesis, the interference with nucleotide metabolism, and the modification of membrane-linked enzyme activity are reported. A possible mechanism of chromium action is proposed. |
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