Smo基因在结肠癌组织中的表达及其与术后肝转移的关系

目的:探讨结肠癌组织中Smo基因的表达及其临床意义。方法:应用免疫组织化学SP法检测96例结肠癌组织中Smo蛋白的表达,并分析其与临床病理指标及术后肝转移的关系。结果:正常结肠组织中Smo蛋白阳性表达率显著低于结肠癌组织(34.6%vs 66.7%,P<0.05),高T分期组、有淋巴结转移组阳性表达显著高于低T分期组及无淋巴结转移组(P<0.05);Smo蛋白阳性表达在性别、年龄、肿瘤大小、分化程度等组间差异无统计学意义(P>0.05)。Smo蛋白阴性表达组结肠癌术后肝转移时间显著迟于阳性表达组(48.73±8.02)月vs(27.98±6.86)月,P<0.01]。结论:结肠癌组织中Smo蛋白异常表达参与了结肠癌的发生、发展,对结肠癌术后肝转移有一定的促进作用;Smo蛋白表达情况可以作为结肠癌术后肝转移的预测因子。

Expression of smo gene in colon cancer and its association with postoperative liver metastasis

Objective： To investigate the expression of Smo protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis.Methods： Expression of Smo was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer.Relationship between Smo expression and clinicopathological parameters,postoperative liver metastasis were analyzed.Results： Smo protein expression was significantly increased in colon cancer tissues compared to normal colon tissues（P〈0.05）.Smo expression in colon tissues was increased in patients with lymph node metastases（P〈0.05） and higher T stages（P〈0.05）.Postoperative live metastasis-free survival period was significantly longer in low Smo expression group than that of high Smo expression group（48.73±8.02 vs 27.98±6.86 months,P〈0.01）.Multivariate analysis showed that Smo expression level is an independent prognostic factor for postoperative live metastasis-free survival.Conclusion： Colon cancer is associated with an upregulation of Smo protein expression in colon tissues.In patients with colon cancer,Smo expression level is closely related to lymph node metastases,T stages and postoperative live metastasis-free survival periods,indicative of a possible role of Smo expression in colon cancer progression.