Establishing the standard method of cochlear implant in Rongchang pig |
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| Authors: | Wei Chen Haijin Yi Liang Zhang Fei Ji Shuolong Yuan Yue Zhang |
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| Institution: | 1. Department of Otolaryngology, Head &2. Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, PR China;3. Department of Otolaryngology, Chinese PLA General Hospital of Air Force, Beijing, PR China;4. Neck Surgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, PR China;5. Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science, Chongqing, PR China |
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| Abstract: | Conclusions: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic.Objective: The aim of this study was to establish a standard method of cochlear implant in a large mammal—pig.Methods: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf?+/+) and mutation group with hearing loss (Mitf ?/?). Cochlear implants were used and ABR and EABR were recorded. The implanted electrodes were observed by X-ray and HE stains.Results: The success with cochlear implant and the best electrode position could be defined in all animals, the coiling of the cochlea reached 1.5–1.75 turns. Immediately after the operation of cochlear implants, the ABR threshold of the operated ear (right) could not be derived for each frequency at 120?dB SPL. Moreover, 7 days after surgery, the low-frequency ABR threshold of the operated ear (right) could be derived partly at 100?dB SPL, but the high-frequency ABR threshold could not be derived at 120?dB SPL. Immediately or 1 week after cochlear implants, the EABR threshold was 90?CL in the Mitf?+/+?group. This was obviously lower than the 190?CL in the Mitf ?/? group. |
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| Keywords: | Cochlear implant Rongchang pig ABR EABR |
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