放射性核素235U对新生大鼠体格生长的影响

目的 研究＾２３５Ｕ脑内照射对新生儿大鼠生长发育的影响。方法 新生大鼠（〈２４ｈ）于侧脑室单次注入２μｌ不同浓度的＾２３５Ｕ，各组大鼠的浓度分别为０、１、５、１０μｇ，观察α射线对新生大鼠早期生长发育的影响。结果 在研究组中，体重增长的下降最为明显，与对照组相比有显著性差异；脑重／体重的比值、张耳、体毛生长、萌牙时间在各组中无明显差异；而开眼时间、游泳运动在不同剂量照射组中均有延迟，并与剂量相关。结论 新生大鼠脑内照射＾２３５Ｕ后可导致生长发育的迟缓。

Effect of Cerebrum Exposure to Alpha Irradiation by235U on Physical Growth and Development of Neonatal Rats

【Objective】 Effects of cerebrum exposure to alpha irradiation from radionuclide235U on physical growth and de-velopment of neonatal rats were studied. 【Methods】 Neonatal rats were irradiated with one single injecting 2μl alpha radionuclidefrom235U into the left lateral ventricle of the rat brain at postnatal 1(<24h) at a dose of 0、1、5、10μg of235U,respectively. These ratswere observed for the early physical growth and development. 【 Results】 In the irradiation group, weight increase was lower anddifferent significantly from those in the controls. Of groups there were not statistically in the radio of brain weight/body weight, bodyhair sprouted, pinna erected, incisor eruption. The retardation in irradiation group was found and different significantly from those in thecontrols such the age of acquisition in physiologic markers as eye opening,movement and coordination function and activty as swim-ming. For most parameters there was a dose-dependent effect. 【 Conclusions】 The neonatal rats having cerebrum exposure to alphairradiation by235U showed delayed growth and abnormal development.