In vitro model for the response to irradiation of different types of human intracranial tumours |
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| Authors: | H. Fischer G. H. Hartmann V. Sturm K. Schwechheimer O. Krauss G. Schackert St. Kunze |
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| Affiliation: | (1) Present address: Deutsches Krebsforschungszentrum, Federal Republic of Germany;(2) Institut für Virusforschung und Zentrale Einrichtung Strahlenschutz und Dosimetrie, Universität Heidelberg, Federal Republic of Germany;(3) Neurochirurgische Abteilung des chirurgischen Zentrums und Institut für Neuropathologie, Heidelberg, Federal Republic of Germany |
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| Abstract: | Summary Twenty-seven human low and high grade gliomas and five meningiomas were cultured in vitro as tumour tissue and/or tumour cells. Cell survival or growth was taken as a measure of radiation response. Astrocytomas II–III and glioblastomas manifested individual patterns of radiosensitivity, ranging from 10 to 90 Gy. Meningiomas did not react. Our findings are consistent with the differences in radiosensitivity of human gliomas experienced clinically and corroborate the validity of the in vitro model. |
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| Keywords: | Intracranial tumours biopsy in vitro irradiation radiosensitivity |
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