The bacterial ribosome,a promising focus for structure-based drug design |
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Authors: | Knowles David J C Foloppe Nicolas Matassova Natalia B Murchie Alastair I H |
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Affiliation: | RiboTargets, Granta Park, Abington, Cambridge, UK. dknowles@ribotargets.com |
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Abstract: | Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes. |
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