男性高血压患者QCT检测与腰椎骨密度的相关性

目的 应用QCT测量腰椎骨密度,探讨男性高血压患者血压水平与腰椎骨密度之间的相关性。方法 选取2020年12月至2022年1月于青岛市市立医院住院男性患者361例,年龄21~80岁;收集其一般资料,按照血压分为正常血压人群、高血压1级人群、高血压2级人群、高血压3级人群;对其行上中腹部CT平扫,使用定量CT获取腰椎骨密度,按照腰椎BMD测量值分为骨量正常组、低骨量组、骨质疏松组。结果 在各年龄人群中,不同骨量组BMI、总胆固醇（TC）、高密度脂蛋白（HDL-C）及低密度脂蛋白（LDL-C）之间的差异无明显统计学意义（P＞0.05）,在51~65岁组、66~80岁组中,腰椎骨密度随三酰甘油（TG）的升高而减低（P＜0.05）。在51~65岁年龄组中,不同血压等级人群的腰椎骨密度差异具有统计学意义（P＜0.05）,高血压病程、SBP、DBP、PP与腰椎骨密度呈负相关（P＜0.05）。50岁以上中老年人血压分级越高,低骨量及骨质疏松发病率越高。多元线性逐步回归分析结果显示年龄、SBP、TG、BMI最终进入方程。结论 50~65岁男性人群高血压与骨密度有一定相关性。年龄、SBP及TG是腰椎骨密度降低的独立危险因素,BMI是腰椎骨密度降低的保护因素。

Study of the correlation between hypertension and bone mineral density of the lumbar vertebrae in males with QCT

Objective Quantitative CT (QCT) was used to measure the bone mineral density (BMD) of the lumbar vertebrae to explore the correlation between blood pressure level and BMD of lumbar vertebrae in male hypertension patients. Methods A total of 361 male patients aged 21-80 years who were hospitalized in Qingdao Municipal Hospital from December 2020 to January 2022 were selected. Their general information was collected and they were divided into normal blood pressure group, hypertension grade 1 group, hypertension grade 2 group and hypertension grade 3 group according to their blood pressure. The abdominal CT scan was performed, and quantitative CT was used to obtain lumbar bone density. According to the measurement value of lumbar BMD, the patients were divided into normal bone mass group, low bone mass group and osteoporosis group. Results There were no significant differences in BMI, TC, HDL-C and LDL-C between different BMD groups in different age groups (P > 0.05). In 51~65 years group and 66~80 years group, the BMD of lumbar vertebra decreased with the increase of TG (P < 0.05). Only in the age group of 51 to 65 years, lumbar BMD of different blood pressure grades was significantly different (P < 0.05), and the course of hypertension, SBP, DBP and PP were negatively correlated with lumbar BMD (P < 0.05). The higher the blood pressure grade was, the higher the incidence of low bone mass and osteoporosis was. Multiple linear stepwise regression analysis showed that age, SBP, TG and BMI could into the equation finally. Conclusions There is a certain correlation between hypertension and BMD in males aged from 50 to 65 years. Age, SBP and TG were independent risk factors for decreased lumbar bone mineral density, while BMI was a protective factor for decreased lumbar bone mineral density.