钾离子通道与肥胖致心律失常的研究进展

肥胖易诱发心律失常,并且治疗手段有限。现有证据表明肥胖致心律失常与心脏钾离子通道异常有关。研究肥胖患者心脏钾离子通道功能表达和电生理机制,有利于提高对肥胖致心律失常的认识,发现新的致病机制,找出新的治疗靶点,对于肥胖患者意义重大。本文旨在探讨心脏钾离子通道与肥胖致心律失常的研究进展。

Research progress in potassium channel and arrhythmia induced by obesity

Obesity predisposes to arrhythmia and treatment is limited. Existing evidence suggests that obesity-induced arrhythmia is associated with abnormal cardiac potassium channels. The study of cardiac potassium channel expression and electrophysiological mechanism in obese patients should improve understanding of obesity-induced arrhythmia, potentially discover new pathological mechanisms, and identify potentially new therapeutic targets. Given the worldwide epidemic of obesity, this information could be highly beneficial for obese patients. This article, therefore, reviews research progress of cardiac potassium channels and arrhythmia induced by obesity.