Short-term prognostic value of serum neuron specific enolase and S100B in acute stroke patients |
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| Authors: | Sergio González-García Alina González-Quevedo Otman Fernández-Concepción Marisol Peña-Sánchez Caridad Menéndez-Saínz Zenaida Hernández-Díaz Marianela Arteche-Prior Alejandro Pando-Cabrera Carlos Fernández-Novales |
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| Affiliation: | 1. Critical Care Medicine Research Group, Department of Intensive Care, Tampere University Hospital, Tampere, Finland;2. Department of Surgical Sciences, Division of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden;3. Faculty of Social Sciences, University of Tampere, Tampere, Finland;4. The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere, Tampere University Hospital, Tampere, Finland;5. Department of Neurology, University of Tampere and Tampere University Hospital, Tampere, Finland |
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| Abstract: | ObjectiveTo explore the value of blood markers for brain injury as outcome predictors in acute stroke.Design and methodsThe study included 61 patients with acute stroke (44 ischemic and 17 hemorrhagic) and a high risk control group (79 individuals with no known history of neurological disease).Serum neuron specific enolase (NSE) and S100B were determined by immunoassay (CanAg Diagnostics, Sweden). Outcome at 60 days was evaluated with clinical scales.ResultsHigher concentrations of NSE and S100B were measured in patients compared to high risk controls, but they were not related to stroke severity on admission. NSE was associated with functional neurological outcome at 60 days and to the degree of recovery, whereas S100B exhibited a strong correlation with depression symptoms at 60 days.ConclusionsThe measurements of serum concentrations of NSE and S100B after acute stroke may be clinically relevant for predicting functional neurological outcome and post-stroke depression, respectively. |
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