慢性前列腺炎病原菌感染特征及危险因素分析

目的 分析慢性前列腺炎（CP）病原菌感染特征及危险因素，为降低CP病原菌感染及临床预防治疗提供理论依据。方法 收集2010年1月 - 2017年12月门诊及住院CP治疗患者826例，分析病原菌感染特征，并采用单因素及多因素logistic回归分析病原菌感染的危险因素。结果 826例CP病人中培养阳性患者482例，感染率为58.35%。482例患者检出病原菌520株，G+球菌448株（86.15%）、G-杆菌49株（9.42%）、G+杆菌23株（4.42%）。G+球菌以表皮葡萄球菌为主，G-杆菌以大肠埃希菌为主。各病原菌对抗菌药物表现出不同程度耐药性。多因素logistic回归分析显示有尿路感染史、每周手淫次数≥2次、每周性生活次数≥4次、长时间憋尿史、固定体位时间≥3 h、性伴侣感染、酗酒是发生CP病原菌感染的独立危险因素（P＜0.05）。结论 临床应根据病原菌药敏结果及药代动力学知识正确合理选择抗菌药物，提高治愈率,制定防治危险因素的措施，减少感染的发生。

Analysis on the characteristics and risk factors of pathogenic bacteria infection in chronic prostatitis

Objective The aim of this study was to analyze the characteristics and risk factors of chronic prostatitis (CP) pathogenic bacteria infection, and thus to provide theoretical basis for reducing CP pathogen infection and clinical prevention and treatment. Methods From January of 2010 to December of 2017, 826 outpatients and inpatients with CP treatment were collected. To analyze the characteristics of pathogen infection, univariate logistic regression and multivariate logistic regression were used to analyze the risk factors of pathogen infection. Results Among 826 CP patients, 482 patients were positive in culture, with an infection rate of 58.35%. 520 strains of pathogenic bacteria were detected in 482 patients. There were 448 strains of G+ coccus (86.15%), 49 strains of G- bacillus (9.42%) and 23 strains of G+ bacillus (4.42%). G+ coccus was dominated by Staphylococcus epidermidis and G- bacillus was dominated by Escherichia coli. All pathogenic bacteria showed different degrees of resistance to antibacterial drugs. Multivariate logistic regression analysis showed that urinary tract infection, masturbation more than 2 times a week, have sex more than 4 times a week, holding urine for longer than 3 hours, sexual partner infection and alcoholism were independent risk factors for CP pathogen infection(P<0.05). Conclusion Clinically, antibacterial drugs should be correctly and reasonably selected according to the drug sensitivity results and pharmacokinetic knowledge of pathogenic bacteria. The cure rate is improved. Formulate measures are needed to prevent and control risk factors and reduce the occurrence of infection.