| 内皮祖细胞来源外泌体在血管生成中作用的研究进展 |
| |
| 引用本文： | 王刚,时光旭,韩骅,梁亮.内皮祖细胞来源外泌体在血管生成中作用的研究进展[J].心脏杂志,2019,31(5):588-591. |
| |
| 作者姓名： | 王刚 时光旭 韩骅 梁亮 |
| |
| 作者单位： | 1.医学遗传学与发育生物学教研室 空军军医大学基础医学院 |
| |
| 基金项目： | 肿瘤生物学国家重点实验室自主课题资助（CBSKL2017Z19、CBSKL2014Z01）；空军军医大学军事医学提升计划项目资助（2018HKTS09） |
| |
| 摘 要： | 内皮祖细胞最早在外周血中被发现，随着内皮祖细胞的相关研究不断丰富，发现内皮祖细胞也通过释放外泌体参与到了血管再生过程中。在缺血/再灌注损伤等疾病中，内皮祖细胞外泌体中的microRNA分子起到促进血管再生，以降低缺血/缺氧微环境带来的损伤风险并促进组织再生修复的作用。因此，内皮祖细胞外泌体已经被看作是血管再生的重要因素。本文就近年来内皮祖细胞来源外泌体在血管生成中作用的研究进展做一综述，以期为血管损伤相关疾病的治疗提供新思路。
|
| 关 键 词： | 血管生成 内皮祖细胞 外泌体 microRNA |
| 收稿时间： | 2019-04-22 |
Role and mechanism of endothelial progenitor cells derived exosome in angiogenesis |
| |
| Institution: | 1.Department of Medical Genetics and Developmental Biology2.Department of Biochemistry and Molecular Biology3.State Key Laboratory of Cancer Biology4.Third Cadet Regiment5.Fifth Cadet Regiment,School of Basic Medical Sciences, Air Force Medical University, Xi’an 710032, Shaanxi, China |
| |
| Abstract: | Endothelial progenitor cells were first discovered in peripheral blood. With increasing research on endothelial progenitor cells, it was found that endothelial progenitor cells also participate in the process of angiogenesis by releasing exosomes. In diseases such as ischemia-reperfusion injury, microRNA molecules in the exosomes derived from endothelial progenitor cells promote angiogenesis, which can reduce the risk of injury caused by ischemia and hypoxia microenvironment, and promote tissue regeneration and repair. Therefore, endothelial progenitor derived exosomes have been regarded as an important factor in angiogenesis. In this review, recent advances in the role of endothelial progenitor derived exosomes in angiogenesis are reviewed in order to shed a light on the treatment of these diseases such as vascular injury. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
| 点击此处可从《心脏杂志》下载免费的PDF全文 |
|
