血清脂肪因子visfatin、A-FABP与老年高血压血压变异性的相关性

目的 探讨血清visfatin、A-FABP与老年高血压血压变异性（BPV）相关性。 方法 选取2017年1月至2019年2月保定市第二医院收治的老年高血压患者（≥ 60岁）235例，采用ELISA法检测血清visfatin、A-FABP水平，分析不同水平组visfatin、A-FABP与老年高血压24 h平均动脉压（24 hMABP）、24 h舒张压变异率（24 hDBPV）、24 h收缩压变异率（24 hSBPV）的相关性。 结果 采用最大选择检验法确定血清visfatin、A-FABP的截断点分别为43.5 ng/ml、20.9 ng/ml，visfatin低水平组的24 hMABP、24 hDBPV、24 hSBPV较高水平组明显降低（均P < 0.01）。A-FABP低水平组24 hDBPV、24 hSBPV、visfatin显著低于高水平组（均P<0.01）。24 hSBPV与年龄、LDL-C、血清visfatin、血清A-FABP呈正相关（均P < 0.01）。24 hDBPV与年龄、血清visfatin、血清A-FABP呈正相关（均P < 0.01）。 结论 年龄、A-FABP、visfatin是BPV增高的独立相关因素。

Correlation between serum visfatin,A-FABP and blood pressure variability in elderly patients with hypertension

AIM To investigate the correlation between serum visfatin, A-FABP and blood pressure variability in elderly patients with hypertension. METHODS 235 elderly patients with hypertension (> 60 years old) admitted to Baoding Second Hospital from January 2017 to February 2019 were selected. Serum visfatin and A-FABP levels were measured by ELISA. The correlation between visfatin and A-FABP and 24-hour mean arterial pressure (24-hour MABP), 24-hour diastolic pressure variability (24-hour DBPV) and 24-hour systolic pressure variability (24-hour SBPV) was analyzed. RESULTS The optimum threshold values of serum visfatin and A-FABP were 43.5 ng/ml and 20.9 ng/ml respectively. The 24-hour MABP, 24-hour DBPV and 24-hour SBPV in the group of visfatin < 43.5 ng/ml were significantly lower than those in the group of visfatin ≥ 43.5 ng/ml (P < 0.01). The 24-hour DBPV, 24-hour SBPV and visfatin in group A-FABP < 20.9 ng/ml were significantly lower than those in group A-FABP ≥ 20.9 ng/ml (P < 0.01). 24 hSBPV was positively correlated with age, LDL-C, serum visfatin and serum A-FABP, and the difference was statistically significant (all P < 0.01). 24 hDBPV was positively correlated with age, serum visfatin and serum A-FABP (all P < 0.01). CONCLUSION Age, A-FABP and visfatin are positively correlated with the increase of BPV, while BPV is closely correlated with target organ damage in elderly patients with hypertension.