IgE-mediated allergy to recombinant human insulin in a diabetic |
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| Authors: | Baur X Bossert J Koops F |
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| Affiliation: | Ordinariat und Zentralinstitut für Arbeitsmedizin Hamburg, Hamburg; Gemeinschaftspraxis Mannheim, Mannheim, Germany. |
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| Abstract: | A 63-year-old nonatopic female suffering from type II diabetes with severe local and systemic immediate-type allergic reactions to injections of different recombinant human insulin products has been reported. Skin testing as well as IgE measurements not only proved immediate-type sensitization to human insulin but also to porcine and bovine insulin which had never been administered and indicated immunological cross-reactivity. Cross-reactivity was proved by an IgE inhibition test. Independent of this reaction, the patient showed IgE-mediated sensitization to protamine. |
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| Keywords: | insulin allergy protamine allergy IgE antibodies urticaria skin testing |
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