| Oxaliplatin combined with 5-fluorouracil, leucovorin regimen for patients with advanced colorectal cancer |
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| 作者姓名： | Suyi Li Lin Liu Xiaoyi Gu Zao Jiang Cailian Wang |
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| 作者单位： | Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University, Nanjing 210009, China |
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| 摘 要： | Objective： To observe the efficacy and tolerability of continuously infusing 5-fluorouracil （5-FU） / folic acid combined with oxaliplatin （L-OHP/5-FU/LV regimen） as first line treatment in advanced colorectal cancer. Methods： 23 patients of advanced colorectal cancer were treated with 5-FU 500 mg/d, civ, d 1-d5, d8-d12, leucovorin 100 mg/d, iv gtt, d1, d8, folic acid tablet 60 mg/d, po, d2-d5, d9-d12, and oxaliplatin 65 mg/（m^2·d）, iv gtt, dl, d8, repeated every 21 days （one cycle）. The effect was evaluated after two cycles. Results： Complete response in 2 cases and partial response in 10 cases were observed with an overall response rate of 47.18%. Adverse effects were mainly grade 1-2, including nausea, vomiting, diarrhea, dental ulcer, peripheral neuritis and myelosuppression. Conclusion： L-OHP/5-FU/LV regimen is an effective and better tolerated alternative treatment in advanced colorectal cancer and yields promising clinical application.
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| 关 键 词： | 氟二氧嘧啶 抗癌药 结肠癌 治疗方法 |
| 收稿时间： | 1 January 2007 |
| 修稿时间： | 2007-01-012007-02-15 |
Oxaliplatin combined with 5-fluorouracil,leucovorin regimen for patients with advanced colorectal cancer |
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| Suyi?Li,Lin?Liu,Xiaoyi?Gu,Zao?Jiang,Cailian?Wang.Oxaliplatin combined with 5-fluorouracil, leucovorin regimen for patients with advanced colorectal cancer[J].The Chinese-German Journal of Clinical Oncology,2007,6(3):P225-P227. |
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| Authors: | Suyi Li Lin Liu Xiaoyi Gu Zao Jiang Cailian Wang |
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| Institution: | (1) Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University, Nanjing, 210009, China |
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| Abstract: | ObjectiveTo observe the efficacy and tolerability of continuously infusing 5-fluorouracii(5-FU)/folic acid combined with oxaliplatin(L-OHP/5-FU/Lv regimen)as first line treatment in advanced colorectal cancer.Methods23 patients of advanced colorectal cancer were treated with 5-Fu 500mg/d,civ,d1-d5,d8-d12,leucovorin 100mg/d,iv gtt,d1,d8,folic acid tablet 60 mg/d,po,d2-d5,d9-d12,and oxaliplatin 65mg/(m2-d),iv gtt,d1,d8,repeated every 21 days(one cycle).The effect was evaluated after two cycles.ResultsComplete response in 2 cases and partial response in 10 cases were observed with an overall response rate of 47.18%.Adverse effects were mainly grade 1-2,including nausea,vomiting,diarrhea,dental ulcer,peripheral neuritis and myelosuppression.ConclusionL-OHP/5-FU/LV regimen is an effective and better tolerated alterna tive treatment in advanced colorectal cancer and yields promising clinical application. |
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| Keywords: | advanced colorectal cancer oxaliplatin 5-fluorouracil leucovorin combination chemotherapy |
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