左氧氟沙星序贯疗法治疗社区获得性肺炎疗效观察

目的：观察左氧氟沙星治疗社区获得性肺炎（CAP）的疗效.方法：将84名患者随机分为序贯疗法组和对照组,每组42人,两组患者均在给予退热、止咳、平喘等对症治疗的基础上,对照组给予左氧氟沙星持续静脉给药;序贯疗法组采用同类药物静脉滴注3~4d,症状明显改善后改用同类药物口服,两组总疗程均为10~15d.结果：对照组总有效率为92.9%（39/42）,序贯疗法组总有效率为90.5%（38/42）,两组比较差异无统计学意义（P〉0.05）;对照组平均住院时间（11.5± 2.3）d,序贯疗法组平均住院时间（6.3± 2.4）d,两组比较有统计学意义（P〈0.05）.对照组发生不良反应28.6%（12/42）,序贯疗法组发生不良反应11.9%（5/42）,两者比较有统计学意义（P〈0.05）.结论：应用左氧氟沙星序贯疗法治疗CAP,是一种经济、有效的治疗方法,具有临床可行性,但在临床应用中要注意选择有效的口服抗生素,并掌握合适的时机.

Effect observation of levofloxacin sequential therapy in treatment of community acquired pneumonia

Objective： To observe curative effect of levofloxacin in treatment of community acquired pneumonia （CAP）. Meth- ods ：84 patients were randomly divided into sequential therapy group and control group with 42 cases in each group. Based on the treat- ment for fever, cough, asthma and the like, the cases in control group were continuously intravenously injected with levofloxacin, whereas those in sequential group were intravenously dripped with the similar drug. When the symptoms were improved significantly, the two groups orally took the similar drug. the total course of treatment was both lO-15d. Results： The total effective rates of control group and sequential group were 92.9% （39/42） and 90.5% （38/42） , respectively; there was no significant difference between the two groups （P〉0.05）. The mean hospitalization times of control group and sequential group were （ 11.5 ±2.3 ） d and （6.3±2.4） d, respectively; there was a significant difference between the two groups （P〈0. 05）. The adverse reaction rates of control group and se- quential group were 28.6% （12/42） and 11.9% （5/42）, respectively; there was a significant difference between the two groups （P 〈0.05）. Conclusions： The levofloxacin sequential therapy for treating CAP is an economic and effective method and has the clinical feasibility; however, it should pay attention to choose effective oral antibiotic and use it in the right time.