过敏性疾病家族史对哮喘儿童呼出气一氧化氮的影响

目的：探讨过敏性疾病家族史对哮喘儿童不同临床分期呼出气一氧化氮水平（Exhaled Nitric Oxide,ENO）的影响.方法：收集2012年3月至12月在山东省立医院儿科门诊就诊的哮喘患者（6～14岁）共155例,其中急性发作期患者30例,持续期哮喘患者67例,缓解期哮喘患者58例,三组患者分别根据有无过敏性疾病家族史进行分组,然后分别检测其呼出气一氧化氮水平.结果：①哮喘儿童急性发作期ENO水平明显高于持续期和缓解期;②急性发作期有家族史组患儿ENO水平较无家族史者高,差异有统计学意义（P＜0.05）;持续期和缓解期有家族史患儿ENO水平与无家族史患儿ENO水平差异无统计学意义（P均＞0.05）.结论：有过敏性疾病家族史的哮喘儿童ENO高于无过敏性疾病家族史哮喘儿童ENO水平,提示前者的气道炎症较后者严重.

Influence of family history of allergic diseases on exhaled nitric oxide for children with asthma

Objective：To investigate influence of family history of allergic diseases on exhaled nitric oxide （ENO） levels for children with asthma ih different clinical stages. Methods： 155 children （6-14 years old） with asthma in Shandong provincial hospital from March 2012 to December 2012 were selected, including 30 cases in acute exacerbation stage, 67 cases in duration stage, and 58 cases in remission stage. The patients in the three groups were divided to different subgroups based on the family history of the allergic diseases, and then their ENO levels were detected, respectively. Results ： 1. The ENO levels of the children in the acute exacerbation stage were significantly higher than those of the cases in the duration and remission stages. 2. For the children in the acute exacerba- tion stage, the ENO levels of those with the family history were higher than those of the cases without the family history, and the differ-ences were statistically significant （P〈0.05） ; whereas the differences among the children with or without the family history in the du-ration and remission stages were all not statistically significant （ all P〉0.05）. Conclusions ： The ENO levels are higher for the asthma Children with the family history of the allergic diseases , which suggests they have more severe airway inflammations, than the latter.