|
|||||
|
|
Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation |
|
| Authors: | Elzbieta Kolaczkowska Anna Goldys Elzbieta Kozakiewicz Monika Lelito Barbara Plytycz Nico van Rooijen Bernd Arnold |
| Institution: | 1. Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Kraków, Poland 4. Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060, Kraków, Poland 2. Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, the Netherlands 3. Laboratory for Molecular Immunology, German Cancer Research Center, Heidelberg, Germany |
| Abstract: | IntroductionCyclooxygenases (COXs) play important roles during inflammation. While reports on COX-2 function in inflammation preceded those on COX-1, it is now well established that both isoforms participate in this process. During inflammation, COX expression was reported in inflammatory leukocytes, but much less is known about their presence in tissue- resident leukocytes. The aim was thus to verify the expression and activity of the COX isoforms in resident peritoneal mast cells and macrophages during acute peritonitis. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |