Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma |
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| Authors: | Mei-Fang Zhang Zhi-Yi Zhang Jia Fu Yu-Feng Yang Jing-Ping Yun |
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| Affiliation: | (1) State Key Laboratory of Oncology in Southern China, Cancer Center of Sun Yat-Sen University, Guangzhou, China;(2) Department of Pathology, Cancer Center, Sun Yat-Sen University, 510060 Guangzhou, China |
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| Abstract: | Background Tumor Protein p53 (p53), cyclin-dependent kinase inhibitor 1A (p21/WAF1), and murine double minute 2 (MDM2) participate in the regulation of cell growth. Altered expression of these gene products has been found in malignant tumors and has been associated with poor prognosis. Our aim was to investigate the expression of the 3 proteins in hepatocellular carcinoma (HCC) and their prognostic significance. |
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