Comparative analysis of cell culture and prediction algorithms for phenotyping of genetically diverse HIV-1 strains from Cameroon |
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| Authors: | Viswanath Ragupathy Jiangqin Zhao Xue Wang Owen Wood Sherwin Lee Sherri Burda Phillipe Nyambi Indira Hewlett |
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| Affiliation: | (1) Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 20892 Bethesda, MD, USA;(2) Department of Pathology, NYU School of Medicine, 550 First Avenue, Medical Sciences Building, 5th Floor, 10016 423 New York, NY, USA |
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| Abstract: | Background With the advent of entry inhibitors, monitoring of viral tropism in the clinical setting is important. Conventional methods are cell-based and lengthy, therefore V3 sequence based prediction algorithms are becoming increasingly attractive as monitoring tools. Here we report a comparative analysis of viral tropism of strains circulating in Cameroon where diverse and emerging variant strains are prevalent. |
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