HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function |
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| Authors: | Maik Sossdorf Sascha Marx Barbara Schaarschmidt Gordon P Otto Ralf A Claus Konrad Reinhart Christiane S Hartog Wolfgang Lösche |
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| Affiliation: | (1) Department of Anaesthesiology and Intensive Care Therapy, Jena University Hospital, Erlanger Allee 101, D-07740 Jena, Germany |
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| Abstract: | Introduction Hydroxyethyl starch (HES) solutions are widely used for volume replacement therapy but are also known to compromise coagulation, impair renal function and increase long-term mortality. To test the hypotheses that HES 130/0.4 has fewer adverse effects than HES 200/0.5 and exerts anti-inflammatory properties, we compared the effects of HES 130/0.4, HES 200/0.5 and saline on in vitro haemostasis and pro-inflammatory platelet function. |
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