慢性阻塞性肺疾病患者糖代谢状态对脉搏波速度的影响

目的探讨慢性阻塞性肺疾病（COPD）患者糖代谢状态对脉搏波速度（baPWV）的影响。方法将100例COPD患者分为糖代谢正常（NGT）组、糖调节受损（IGR）组、糖尿病（DM）组，分别测定baPWV、糖代谢异常危险因子、血脂、炎症因子等指标，对所得结果进行比较分析。结果DM组baPWV为（1．87±0．37）m／s，显著高于NGT组的（1．60±0．23）m／s及IGR组的（1．69±027）m／s（P〈0．01）。多元线性回归分析显示。年龄、高敏C反应蛋白和收缩压水平为总体baPWV影响因子，年龄及糖化血红蛋白水平为DM组baPWV影响因子。结论处于糖代谢状态不同阶段COPD患者baPWV有增快趋势，其中以DM患者更为明显。

Association between glucose metabolism status and brachial-ankle pulse wave velocity in patients with COPD

Objective To investigate the association between glucose metabolism status and brachial-ankle pulse wave velocity （baPWV） in patients with chronic obstructive pulmonary disease （COPD）. Methods baPWV values were measured in 100 COPD patients. Plasma glucose, serum lipids, CRP and other baseline data were obtained in all patients. According to the glucose levels patients were classified as normal glucose tolerance （NGT）, impaired glucose regulation （IGR） and diabetes mellitus （DM） groups. Results baPWV values of the DM group （1.87 ± 0.37）m/s were higher than those of NGT （1.60 ± 0.23）m/s and IGR groups （1.69 ± 0.27）m/s. Multiple stepwise linear regression analyses indicated that baPWV values were associated with aging, CRP and SBP levels. In DM groups, higher baPWV valves were associated with aging and HbA1c. Conclusion COPD patients with DM have higher baPWV values, which indicates that the disease is more aggravated in this group of patients.