他克莫司治疗白癜风对病人血清CXCL9、CXCL10水平的影响

目的:探讨他克莫司对白癜风病人血清CXC趋化因子配体9(CXCL9)、CXCL10水平的影响.方法:选取白癜风病人240例,按随机数字表法分为对照组和观察组,各120例.对照组采用常规治疗,观察组在常规治疗基础上加用他克莫司,2组均治疗2个月.比较2组治疗效果,分别在治疗前、治疗2个月后采血检测2组血清CXCL9、CX...

Effect of tacrolimus on the serum levels of CXCL9 and CXCL10 in patients with vitiligo

ObjectiveTo investigate the effects of tacrolimus on the serum levels of CXC chemokine ligand 9(CXCL9) and CXC chemokine ligand 10(CXCL10) in patients with vitiligo.MethodsTwo hundred and forty patients with vitiligo were divided into the control group(n=120) and observation group(n=120) according to the random number table method.The control group was treated with routine treatment, while the observation group was additionally treated with tacrolimus on the basis of routine treatment for 2 months.The therapeutic effects between two groups were compared.The serum levels of CXCL9, CXCL10 and tumor necrosis factor-α(TNF-α) in two groups were measured before treatment and after 2 months of treatment.The correlations between serum levels of CXCL9 and CXCL10, and TNF-α were analyzed using Pearson linear correlation analysis.The adverse reactions in two groups were recorded.ResultsThe total effective rate in observation group was higher than that in control group(P < 0.05).After treatment, the serum levels of CXCL9, CXCL10 and TNF-α in two groups were significantly lower than those before treatment, and which in observation group was significantly lower than that in control group(P < 0.01).The results of Pearson linear correlation analysis showed that the serum levels of CXCL9 and CXCL10 were positively correlated with TNF-α(r=0.713, 0.672, P < 0.01).The differences of the incidence rates of burning, erythema, rash and pruritus between two groups were not statistically significant(P>0.05).ConclusionsCompared with conventional therapy alone, tacrolimus can further reduce the serum levels of CXCL9 and CXCL10 in patients with vitiligo, which may be an important mechanism in improving clinical efficacy, and both of them are positively correlated with TNF-α.