外周血中性粒细胞淋巴细胞比值、血小板淋巴细胞比值、CEA和AFP在原发性肝癌辅助诊断中的临床价值

目的:探讨中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板淋巴细胞比值(platelet to lymphpcyte ratio,PLR)、癌胚抗原(carcinoembryonic antigen,CEA)和甲胎蛋白(alpha fetal protein,AFP...

Clinical value of the peripheral blood neutrophilic to lymphocyte ratio,platelet to lymphocyte ratio,CEA and AFP in the auxiliary diagnosis of primary liver cancer

ObjectiveTo explore the clinical value of single and combined detection of neutrophil to lymphocyte ratio(NLR), platelet to lymphpcyte ratio(PLR), carcinoembryonic antigen(CEA) and alpha fetal protein(AFP) in the early diagnosis of primary hepatocellular carcinoma(HCC).MethodsThe routine blood, CEA and AFP in 95 patients with primary HCC, 90 cases with liver cirrhosis and 100 healthy people in the same period were detected.The clinical value of single and combined detection of NLR, PLR, CEA and AFP in the auxiliary diagnosis of primary HCC were analyzed using the receiver operating characteristic(ROC) curve.ResultsThe levels of NLR, PLR, CEA and AFP in primary HCC group were higher than those in cirrhosis group and control group, and the levels of NLR, PLR, CEA and AFP in cirrhosis group were also higher than those in control group(P < 0.05 to P < 0.01).The areas under the ROC curve, sensitivities and specificities of the single and combined detection of NLR, PLR, CEA and AFP in the auxiliary diagnosis of primary liver cancer were(0.827, 0.602, 0.816, 0.942 and 0.983), (81.2%, 67.2%, 78.6%, 92.5% and 96.7%) and(71.3%, 64.5%, 73.4%, 82.3% and 81.2%), respectively.The areas under the ROC curve, sensitivities and specificities of the single and combined detection of NLR, PLR, CEA and AFP in the differential diagnosis of primary liver cancer were(0.633, 0.701, 0.505, 0.717 and 0.761), (61.3%, 68.7%, 51.2%, 70.6% and 78.3%) and(68.4%, 72.6%, 56.7%, 68.7% and 73.2%), respectively.ConclusionsThe combined diagnostic tests of NLR, PLR, CEA and AFP can improve the sensitivity of auxiliary diagnosis of primary HCC, and have certain clinical application value in the differential diagnosis of liver cirrhosis.