氧自由基、细胞因子、Cortisol与ACVD应激性并发症的相关性

目的：探讨氧自由基、细胞因子、皮质醇（Cortisol）与ACVD患者应激性并发症的相关性及其可能机制。方法：通过观察应激状态下ACVD患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、Cortisol的含量情况,并和无应激反应ACVD患者和健康体检者比较。结果：SOD含量,应激反应组低于无应激反应组（P〈0.05）,无应激反应组低于健康对照组（P〈0.05）。MDA、IL-6、TNF-α和Cortisol含量,应激反应组都高于无应激反应组（均P〈0.05）,无应激反应组均均高于健康对照组（均P〈0.05）。结论：氧自由基、IL-6、TNF-α、Cortisol共同参与了ACVD应激性并发症的发病机制,临床可以通过监测外周静脉血中SOD、MDA、IL-6、TNF-α和Cortisol的含量作为预测ACVD应激性并发症的指标,同时亦可将其作为临床干预效果的观察指标。

Relationship Between Oxygen Free Radicals, Cytokines, Cortisol and Stress Complications in Patients with Acute Cerebrovascular Disease

Objective To investigate the relationship between oxygen free radicals,cytokines,cortisol and stress complications in patients with acute cerebrovascular disease（ACVD）.Methods Serum levels of superoxide dismutases（SOD）,malondialdehyde（MDA）（with biochemistry）interleukin-6（IL-6）,tumor necrosis factor（TNF-α）and cortisol（with RIA）were measured in 32 patients with acute cerebrovascular disease（ACVD）plus stress complications and 48 patients without stress complications as well as 36 controls.Results Serum SOD contents in non-stressed group were higher than those in stressed group（P0.05）but lower than those of the controls（P0.05）.However the levels of MDA,IL-6,TNF-α and cortisol were highest in the stressed group and lowest in the controls（all P0.05）.Conclusion Oxygen free radicals,IL-6,TNF-α and cortisol were involved in stress complications in patients with ACVD.Monitoring the levels of serum SOD,MDA,IL-6,TNF-α and cortisol could be useful for predicting stress complications and evaluating the therapeutic effect.