Chronic constriction model of rat sciatic nerve: nerve blood flow,morphologic and biochemical alterations |
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| Authors: | Hideyuki Sasaki Mikihiro Kihara Paula J Zollman K K Nickander Inge L Smithson James D Schmelzer Catherine L Willner Eduardo E Benarroch P A Low |
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| Institution: | (1) Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA Tel.: 1-507-284-3375; Fax: 1-507-284-1814, US |
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| Abstract: | We evaluated the nerve blood flow (NBF), light and electron microscopy, and adrenergic innervation of rat sciatic nerve at
2–45 days after the application of four loose ligatures. Ischemia developed at the lesion edge, creating an endoneurial dam.
Calcitonin gene-related peptide, norepinephrine and NBF were increased within the lesion. Morphologic alterations consisted
of early endoneurial edema, followed by myelinated fiber degeneration, with relative sparing of small myelinated and unmyelinated
nerve fibers, and leukocyte adhesion to microvessels. Axonal degeneration predominated over demyelination. At 45 days, profuse
regeneration of small myelinated fibers was seen. The mechanism of lesional sensitization is discussed.
Received: 30 May 1996 / Revised, accepted: 13 August 1996 |
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| Keywords: | Pain Sciatic nerve Ischemia Calcitonin gene-related peptide Adrenergic |
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