Non-muscarinic effects of atropine on calcium conductances in cultured mouse spinal cord neurons |
| |
Authors: | B Hedlund D G Owen J L Barker |
| |
Institution: | 1. Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91 Stockholm Sweden;2. Laboratory Neurophysiology, NIH-NINCDS, Bldg. 36, Room 2C02, Bethesda, MD 20205 U.S.A. |
| |
Abstract: | Cultured neurons derived from mouse spinal cord were studied using intracellular recording techniques. Effects of muscarinic cholinergic antagonists (atropine) on voltage-dependent membrane events, which could not be related to muscarinic receptors are described. Atropine (in nanomolar to micromolar concentrations) blocks calcium conductances in a manner which is not blocked by carbachol (100 microM). A direct effect of atropine on membrane Ca2+ conductances is suggested. |
| |
Keywords: | spinal cord neurons atropine calcium channels non-muscarinic effects |
本文献已被 ScienceDirect 等数据库收录! |