Non-muscarinic effects of atropine on calcium conductances in cultured mouse spinal cord neurons |
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| Authors: | B Hedlund D G Owen J L Barker |
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| Institution: | 1. Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91 Stockholm Sweden;2. Laboratory Neurophysiology, NIH-NINCDS, Bldg. 36, Room 2C02, Bethesda, MD 20205 U.S.A. |
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| Abstract: | Cultured neurons derived from mouse spinal cord were studied using intracellular recording techniques. Effects of muscarinic cholinergic antagonists (atropine) on voltage-dependent membrane events, which could not be related to muscarinic receptors are described. Atropine (in nanomolar to micromolar concentrations) blocks calcium conductances in a manner which is not blocked by carbachol (100 microM). A direct effect of atropine on membrane Ca2+ conductances is suggested. |
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| Keywords: | spinal cord neurons atropine calcium channels non-muscarinic effects |
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