| 血清胱抑素C和C反应蛋白联合检测在评估糖尿病肾损害中的应用价值 |
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| 引用本文： | 谭静,殷闯,郭明好,张晓利.血清胱抑素C和C反应蛋白联合检测在评估糖尿病肾损害中的应用价值[J].新乡医学院学报,2013,30(4):290-291. |
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| 作者姓名： | 谭静 殷闯 郭明好 张晓利 |
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| 作者单位： | 1. 新乡医学院第三附属医院肾内科,河南 新乡,453003
2. 新乡医学院第一附属医院肾内科,河南 卫辉,453100 |
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| 摘 要： | 目的探讨联合检测血清胱抑素C(Cys-C)和C反应蛋白(CRP)水平对评估糖尿病早期肾功能损害的临床价值。方法 87例2型糖尿病(T2DM)患者根据尿微量白蛋白水平分为T2DM组47例和糖尿病肾病(DN)组40例,并选择同期体检健康者40例作为对照组;检测3组研究对象血清Cys-C和CRP水平,并进行比较。结果 T2DM组和DN组患者血清Cys-C和CRP水平显著高于对照组,差异均有统计学意义(P<0.05);DN组患者血清Cys-C和CRP水平显著高于T2DM组,差异有统计学意义(P<0.05)。结论 Cys-C和CRP可作为早期评估糖尿病肾损害程度的指标。
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| 关 键 词： | 胱抑素C C反应蛋白 糖尿病 肾损害 |
Serum cystatin C and C reactive protein for evaluating kidney damage in patients with diabetes mellitus |
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| TAN Jing,YIN Chuang,GUO Ming-hao,ZHANG Xiao-li.Serum cystatin C and C reactive protein for evaluating kidney damage in patients with diabetes mellitus[J].Journal of Xinxiang Medical College,2013,30(4):290-291. |
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| Authors: | TAN Jing YIN Chuang GUO Ming-hao ZHANG Xiao-li |
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| Institution: | 1.Department of Nephrology,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Department of Nephrology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453003,Henan Province,China) |
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| Abstract: | Objective To explore the clinical value of serum cystatin C（Cys-C）and C reactive protein（CRP）for evaluating kidney damage in patients with diabetes mellitus.Methods Eighty-seven patients with type 2 diabetes mellitus（T2DM）were divided into T2DM group（n=47）and diabetic nephropathy（DN）group（n=40）according to urine micro-albumin level,while 40 healthy subjects were chosen as control group.The levels of serum Cys-C and CRP were detected and compared among the three groups.Results The levels of serum Cys-C and CRP in T2DM group and DN group were significantly higher than those in control group（P〈0.05）;the levels of serum Cys-C and CRP in DN group were significantly higher than those in T2DM group（P〈0.05）.Conclusion Cys-C and CRP can be used as an early index for the degree of kidney damage in assessment of diabetes. |
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| Keywords: | cystatin C C reactive protein diabetes mellitus kidney damage |
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