序贯疗法与标准三联疗法根除幽门螺杆菌临床疗效比较

目的比较序贯疗法与标准三联疗法根除幽门螺杆菌(HP)的临床疗效。方法将120例HP阳性的胃炎及消化性溃疡患者随机分为对照组和观察组。对照组患者应用三联疗法,给予奥美拉唑、克拉霉素和阿莫西林治疗,疗程1周。观察组患者应用序贯疗法,给予奥美拉唑联合阿莫西林治疗5 d,然后继续给予奥美拉唑、左氧氟沙星联合克拉霉素治疗5 d。比较2组临床疗效及HP根除率。结果观察组治疗显效43例,有效13例,无效4例,总有效率93.3%;对照组治疗显效41例,有效14例,无效5例,总有效率91.7%,2组总有效率比较差异无统计学意义(P>0.05)。观察组HP清除率(88.3%)显著高于对照组(71.7%),差异有统计学意义(P<0.05)。观察组不良反应发生率(10.0%)与对照组(8.3%)比较,差异无统计学意义(P>0.05)。结论序贯疗法较标准三联疗法HP根除率高,且未增加不良反应发生率。

Clinical effect comparison of sequential therapy and triple therapy in eradication of Helicobacter pylori infection

Objective To compare the clinical effect of sequential therapy and triple therapy in eradication of Helicobacter pylori(HP) infection.Methods A total of 120 HP-infected patients diagnosed chronic gastritis or peptic ulcer were randomly divided into control group and experience group with 60 patients each group.The control group were given triple therapy consisted of omeprazole,clarithromycin and amoxicillin treatment for 1 week.The experience group received omeprazole plus amoxicillin for 5 days,and omeprazole plus levofloxacin and clarithromycin for another 5 days.Clinical effect and HP clearance rate were compared between the two groups.Results The experience group had 43 cases of excellence,13 cases of effectiveness and 4 cases of inefficiency,and control group had 41 cases of excellence,14 cases of effectiveness and 5 cases of inefficiency.There was no significant difference of the effective rate between experience group and control group(93.3% vs 91.7%,P>0.05);HP clearance rate in experience group was significantly higher than that in control group(88.3% vs 71.7%,P<0.05).Adverse reaction rates were 10.0% and 8.3% in experience group and control group without significant difference(P>0.05).Conclusion Compared with triple therapy,HP clearance rate of sequential therapy greatly increased,without the increasing of side-effects.