急性一氧化碳中毒后迟发性脑病患者事件相关电位检测的临床价值

目的探讨急性一氧化碳中毒后迟发性脑病(DEACMP)患者的认知功能状况,为其临床寻找客观的实验室依据。方法将66例急性一氧化碳中毒患者根据病情进展是否发生DEACMP划分为DEACMP组和非DEACMP组。分别对2组患者进行了事件相关电位(ERP)检测和长谷川简易智能量表(HDS)评分,并将结果进行比较。结果与非DEACMP组比较,DEACMP组ERP测定中N2、P3波潜伏期延长,P3波幅降低,差异有统计学意义(P<0.01);DEACMP组HDS评分较非DEACMP组明显降低,差异有统计学意义(P<0.01)。DEACMP组ERP成分中P3波潜伏期与HDS评分呈负相关(r=-0.45,P<0.01),而P3波幅与其呈正相关(r=0.44,P<0.01)。结论 DEACMP患者存在明显的认知功能障碍,ERP可作为评价DEACMP患者认知功能的实验室指标应用于临床。

Clinical value of event related potential test for delayed encephalopathy after acute carbon monoxide poisoning patients

Objective To explore the cognition of patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP),in order to find the laboratory indexes for the clinic.Methods A total of 66 patients with acute carbon monoxide poisoning were divided into DEACMP group and non-DEACMP group according to whether making advancement of delayed encephalopathy or not.Event-related potential(ERP)and Hasegawa dementia scale(HDS) were used for the two groups and the results were compared between them.Results Compared with the non-DEACMP group,the latency of N2 and P3 of ERP were significantly longer and the amplitude of P3 was significantly lower in the DEACMP group(P<0.01).The scores of HDS in the DEACMP group were significantly lower than those in the non-DEACMP group(P<0.01).Correlation analysis showed that there was a remarkable negative correlation with the scores of HDS and latency of P3 of ERP in the DEACMP group(r=-0.45,P<0.01),and a significant positive correlation with the amplitude of P3(r=0.44,P<0.01) respectively.Conclusion DEACMP patients have the cognitive dysfunction obviously.ERP test can be used as clinical indexes of cognition for patients with DEACMP.