SLC6A3基因多态性与帕金森病关联性研究Meta分析

目的探讨SLC6A3基因多态性与帕金森病(PD)易感性的关系。方法检索PubMed和中国国家知识资源数据库(CNKI),根据检索词‘dopamine transporter’,‘DAT’,‘SLC6A3’和‘Parkinson's disease or PD’搜集1995年1月至2012年10月关于SLC6A3与PD关系的研究,对相关研究进行同质性检验,合并数据进行Meta分析。结果东亚人群中,SLC6A33'非翻译区(UTR)可变数目串联重复序列(3'VNTR,rs72527228)是10-重复的等位基因为PD保护性等位基因OR:0.78,95%可信区间(CI)(0.65,0.94),P=0.009]。而在高加索人群,3'VNTR未显示等位基因PD易感性差异。在高加索人中,携带SLC6A3启动区域单核苷酸多态性rs2652510 G等位基因,PD发病风险增加(Gvs A,OR:1.26,95%CI(1.04,1.54),P=0.018;GG vs GA+AA,OR:1.37,95%CI(1.03,1.84),P=0.032)。结论SLC6A3基因多态性与PD发病风险相关,在分析SLC6A3基因多态性与PD发病风险关联性时需要考虑种族因素。

Genetic polymorphism of SLC6A3 is a risk factor for Parkinson's disease: a Meta analysis

Objective To explore the association between genetic polymorphism of SLC6A3and the sensitivity of Parkinson′s disease(PD).Methods The study data of associations between SLC6A3and PD were collected based on docuterms which were dopamine transporter,DAT,SLC6A3,Parkinsons disease or PD by searching the PubMed and the Chinese National Knowledge Infrastructure Database(CNKI)from Jan.1995 to Oct.2012.The homogeneity test method was used in the relevant researches.The Meta analysis was used after all data were combined.Results In East Asian populations,SLC6A3 in variable number of tandem repeat in the 3′untranslated region(3VNTR,rs72527228)was allele of 10-repeat,a protective allele of PDOR:0.78,95%confidence interval(CI)(0.65,0.94),P=0.009],but not in Caucasian populations.Genotype GG and allele G of the single nucleotide polymorphism rs2652510 in SLC6A3 promoter region was associated with onset risk of PD in CaucasianG vs A,OR:1.26,95%CI(1.04,1.54),P=0.018;GG vs GA+AA,OR:1.37,95%CI(1.03,1.84),P=0.032].Conclusion Genetic polymorphism of SLC6A3 is involved in the onset risk of PD.But the different ethnicities should be considered when the correlation between genetic polymorphism of SLC6A3 and the onset risk of PD is analyzed.